We show that mutations at specific positions within a protein structure can act as APR suppressors without affecting protein stability ... be avoided altogether in globular proteins, protein ...

However, it is not clear how the sequence encodes the protein ... the stability and thermal unfolding of a protein are properly understood, the properties of proteins with a known structure ...

That was the first time it has been possible to take a globular protein structure and solve it without any additional experimental information. "The overall lesson of this paper is that protein ...

The technique can also be a reliable method for characterizing protein stability (1 ... degree of hydration inside the structure of the protein to name a few. A very rough estimate of the radius (not ...

The researchers devised an innovative metric, known as the effective strain, [2] to detect small but important changes in protein structure that are linked to stability. Looking at thousands of ...

Fibrous proteins have their long, spiral chains folded to form long, thin shapes. They are strong and are generally insoluble in water. Globular ... the difference in structure between a raw ...

Tau proteins ... with a globular protein called tubulin to stabilize microtubules and aid the assembly of tubulin in the microtubules. Tau proteins achieve their control of microtubule stability ...

Learn about our Editorial Policies. While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and ...

Around this time, Wüthrich was developing 2D NMR as a way of studying proteins, so after my PhD I got a research fellowship to work in his lab, where I was lucky enough to work on the first NMR ...

That was the first time it has been possible to take a globular protein structure and solve it without any additional experimental information. “The overall lesson of this paper is that protein ...