Kickoff from Caesars Superdome is set for 1 p.m. ET. San Francisco is a 3-point favorite in the latest 49ers vs. Saints odds from SportsLine consensus, while the over/under for total points scored is set at 40.5. Before making any Saints vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

With Brock Purdy ruled out of Sunday's game against the New Orleans Saints, the San Francisco 49ers have named Mac Jones their starter. But Jones needs a backup and the 49ers found a surprise pick to fill the role.

Kyle Shanahan explains why the team had to move on from kicker Jake Moody after its Week 1 win Jake Moody began his tenure with the San Francisco 49ers on a promising note, earning the honor of being selected in the third round of the 2023 NFL Draft.

The first thing Staley did as Saints DC was trade for 330-pound nose guard Davon Godchaux, an absolute beast who is a nightmare to handle at the 0 technique. Thoughts and prayers to Niners center Jake Brendel this week.

The San Francisco 49ers downed the Seattle Seahawks in Week 1. How did it affect how Kyle Shanahan's team is being viewed in Week 2.

The San Francisco 49ers and New Orleans Saints meet Sunday in Week 2 at Caesars Superdome in New Orleans, Louisiana.

Martinez will serve as Mac Jones’ backup. He was undrafted out of the 2023 NFL Draft. Martinez has not thrown a regular-season pass in the NFL. The 49ers are hoping it stays that way, although Kyle Shanahan did say he was happy with how Martinez ran scout team practice this past week.