Molecular determinants and signaling effects of PKA RIα phase separation. Molecular Cell , 2024; 84 (8): 1570 DOI: 10.1016/j.molcel.2024.03.002 Cite This Page : ...

cAMP mediates various signaling events by binding to the regulatory domain of PKA, one of its downstream targets. Upon binding, the regulatory domain disassociates from the catalytic domain and ...

The process of the cAMP signaling pathway depends upon PKA. Generally, H89 is utilized as PKA inhibitor. H89 is a potent, cell permeable, and selective inhibitor of PKA, dependent on cAMP.

It’s called the cAMP/PKA signaling pathway for its two main actors — cAMP (cyclic adenosine monophosphate) and PKA (cAMP-dependent protein kinase). When cAMP receives a signal from the cell ...

Parasitology: Exotic signaling mechanism in pathogens Date: April 2, 2019 Source: Ludwig-Maximilians-Universität München Summary: The unicellular parasite that causes sleeping sickness differs ...

The article "Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo" was published in Neuron, at doi: 10.1016/j.neoron2015.12.019 Journal Neuron ...

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that ...

Dopamine activates a protein called PKA in striatal neurons, ... Dopamine signaling pathway that controls cocaine reward in mice identified (2016, February 24) ...

They found a novel mechanism whereby hedgehog signaling goes through PKA-C to activate the pathway. This opens up a new understanding and possible a new drug target,” he told us. Study ...

Pathways enriched in overlapping differentially expressed genes from these datasets were clustered using Jaccard similarity to identify pathways enriched in ILC. The cAMP/PKA/CREB signaling was ...