Under Kyle Shanahan, the San Francisco 49ers have tended to either dominate as NFC contenders or succumb to a rash of season-crushing injuries. And the 2025 campaign just might be continuing that trend for the worse.

If the 49ers don't prepare Mac Jones properly for these two facets against the Saints, it's going to be a long day for them offensively.

The San Francisco 49ers take on the New Orleans Saints at 10:05 a.m. PT on Sunday, Sept. 14 at the Caesars Superdome in New Orleans. The Niners are not expected to have quarterback Brock Purdy or tight end George Kittle for the Week 2 matchup as both suffered injuries in the season-opening win in Seattle over the Seahawks.

The San Francisco 49ers are set to face off against the New Orleans Saints this Sunday and they will be doing so without some key players. The Saints will also be missing some players as edge rusher Chase Young,