Michigan State vs. USC picks, predictions, odds
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The USC Trojans are coming off a road win again the Purdue Boilermakers and now look ahead to their Big Ten home opener against the Michigan State Spartans. USC
There is good news for the 517 registered Michigan State alums living in Thailand. As someone who lives in the Central time zone, I can tell you that the 11 a.m. college football kickoff is absolutely perfect. That’s when they’ll get MSU-USC in Bangkok — throw some moo ping on the grill and let the Mekhong flow!
Michigan State was a betting favorite in all three of its nonconference games to start the season. The Spartans won all three but didn’t cover the spread in any and will now be a double-digit underdog in their Big Ten opener.
Find single game tickets to the USC vs. Michigan State college football matchup on Saturday, September 20, 2025.
The No. 25 USC Trojans are 3-0 and are ranked for the first time in 2025, but the Big Ten gauntlet is set to begin as USC opened conference play with a road win
Smith said offensive guard Luka Vincic and kick returner Alante Brown are both out “long term,” and in the case of Vincic more than likely the rest of the season. Star wide receiver Nick Marsh and starting running back Makhi Frazier will return at some point this season.
A week after playing in Big Ten After Dark on Sept. 20, it will be Big Ten Before Breakfast for the Trojans on Sept. 27 in Champaign
The Michigan State Spartans are 3-0 heading into a crucial road matchup vs. the USC Trojans next Saturday. MSU fans will want to put an extra pot of coffee on