Lions vs Bills in Week 2 at Highmark Stadium
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First came the rumor Monday night, and then came the somewhat surprising confirmation, straight from the Buffalo Bills. The new Highmark Stadium will host its first regular-season game Sept. 17 on Amazon Prime’s Thursday Night Football in a Week 2 game against the Detroit Lions.
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Detroit Lions schedule release: The Lions' first prime time game and opponent are set for week 2 of the 2026 season
The Lions will be on primetime right away in 2026 as they head to the AFC to play on Thursday Night Football
The latest 2026 NFL schedule leak indicates that the Detroit Lions are set to make NFL history in Week 2 of the upcoming season.
The Lions’ path back to Super Bowl contention won’t be easy in 2026. With the schedule release coming May 14, matchups against the Bills, Patriots and Giants already stand out as Detroit’s toughest non-divisional tests.
The New York Giants will open the 2026 NFL season at home on Sunday Night Football against the Dallas Cowboys.