Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional ...

Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity and mortality. There have been significant management advances over the past 2 decades, but the burden ...

There is a growing appreciation for differences in epidemiology, treatment, and outcomes of cardiovascular conditions by sex. Historically, cardiovascular clinical trials have under-represented ...

The past decade has seen increasing interest in the tricuspid valve (TV), once referred to as the forgotten valve, as a result of a combination of improved imaging and therapeutic possibilities plus a ...

For >50 years, immune cells, comprised of lymphocytes and myeloid-like cells, have been observed in blood vessels and kidneys of humans with hypertension, and various experimental models, including ...

Aim: This executive summary of the clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain ...

Aortic valves from EgfrVel/+ mice and control mice were examined by light microscopy at 2.5 to 4 months of age. Additional EgfrVel/+ and control mice underwent echocardiography at 2.5, 4.5, 8, and 12 ...

Abstract —Short-term feeding (up to 7 days) of an atherogenic diet to C57BL/6 low density lipoprotein receptor–deficient mice did not result in decreased hepatic paraoxonase (PON) mRNA but caused a ...

Graphical AbstractIntracranial atherosclerotic stenosis (ICAS) is the most common cause of stroke worldwide and is associated with high risk of recurrence compared with other stroke subtypes. 1–3 ...

Background—We hypothesized that high-sensitivity cardiac troponin (hs-cTn) and its early change are useful in distinguishing acute myocardial infarction (AMI) from acute cardiac noncoronary artery ...

A comprehensive literature search was conducted from September 14, 2022, to November 22, 2022, encompassing studies, reviews, and other evidence on human subjects that were published in English from ...

We identify a previously unknown pathway by which cardiac HIF activation promotes the loss of mitochondria and peroxisomes. We found that DEPP1 (decidual protein induced by progesterone 1) is induced ...