An Aussie had a career day, and the rookie throwers are starting to make their mark as the NFL reached week five.

Nine teams scored 30-plus points and three games combined for 60 or more. Captain Kirk Cousins threw for a whopping 509 ...

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

This was easily Purdy's worst fantasy game through weeks, but fantasy managers shouldn't panic about their quarterback the way 49ers' fans are panicking about their team's Super Bowl hopes.

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

San Francisco's defense rebounded against the Patriots but faces a tougher test in Murray's dynamic playmaking ability. Brock ...

Using Samuel in the backfield isn’t a novel concept, but it’s one the 49ers have gone away from since his breakout All-Pro ...

Tagovailoa sustained at least the third concussion of his career in Week 2’s 31-10 loss to the Buffalo Bills. On Sept. 17, ...

By then, perhaps the 49ers could have rookie Ricky Pearsall on the field as they take on the Cowboys and the Chiefs. So, ...