The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The Arizona Cardinals and San Francisco 49ers play in Week 5 Sunday afternoon at Levi's Stadium with a 1:05 p.m. Arizona time ...

The San Francisco 49ers will wear alternate throwback uniforms that feature white pants to prepare for projected record-breaking temperatures during the team's Week 5 matchup with the Arizona ...

The following player has been promoted to the active roster from the team's practice squad: The 49ers announced that TE George Kittle has been ruled out for the team's Week 3 matchup vs.

Slowly but surely the 49ers are starting to place trust in their rookies. They showed it in their Week 4 win against the Patriots. There was one intriguing takeaway from the 49ers' Week 4 win ...

The San Francisco 49ers have begun to turn the page to their younger players. They signaled those changes in their Week 4 victory against the New England Patriots. Rookie safety Malik Mustapha got ...

San Francisco 49ers head coach Kyle Shanahan addressed running back Christian McCaffrey's bilateral Achilles tendonitis for the first time, following comments made by general manager John Lynch.

The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

The San Francisco 49ers today announced the team has signed LB Jalen Graham to a one-year deal. Graham (6-3, 220) was originally drafted by the 49ers in the seventh round (255th overall ...

The San Francisco 49ers are reinforcing the roster with two new additions, while also opening up the practice window for DL Kalia Davis. The injury bug has struck the 49ers over the past four ...