The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The San Francisco 49ers will wear alternate throwback uniforms that feature white pants to prepare for projected record-breaking temperatures during the team's Week 5 matchup with the Arizona ...

To describe the San Francisco 49ers’ 23-17 loss against the Minnesota Vikings on Sunday as a comedy of errors would be an understatement. After a dominant performance where they played like the ...

The San Francisco 49ers finally had good news on their practice participation report. Every player on the 53-man roster participated in Thursday's practice leading up to Week 2.

Pearsall (chest) won't return to practice this week, Lindsey Pallares of the 49ers' official site reports. Coach Kyle Shanahan made the announcement Wednesday, two days after telling reporters a ...

The San Francisco 49ers apparently came extremely close to trading Brandon Aiyuk to the Pittsburgh Steelers. The team was actually on the phone with the Steelers when Aiyuk arrived at the 49ers ...

The San Francisco 49ers will be without star running back ... The USA TODAY app gets you to the heart of the news — fast. Download for award-winning coverage, crosswords, audio storytelling ...

San Francisco 49ers star running back Christian McCaffrey could be out for six weeks or more due to his calf soreness and Achilles tendinitis, according to NFL Network's Ian Rapoport. Rapoport ...

McCaffrey is a do-it-all back that gives defenses fits. The 49ers have talent all over their offense but it starts with McCaffrey. He rushed for 1,459 yards and 14 touchdowns last season and had ...

There was a moment. There was. The Jets defense had registered a stop, then stiffened after a Breece Hall fumble deep in their own end, holding the 49ers to a field goal. Now it was Aaron Rodgers ...