The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 ...

Angiotensin II receptor blockers prevent angiotensin from reaching some of the sites it binds to in the kidneys, heart, and blood vessels. The results of this action lower blood pressure and help ...

Antibodies to the angiotensin II type 1 (AT1) receptor may contribute to a wide range of kidney abnormalities. Dragun et al. found that patients with refractory vascular allograft rejection ...

Angiotensin II receptor blockers (ARBs) ... ARBs block certain receptors of angiotensin II. These receptors, known as AT1 receptors, are found in the heart, blood vessels, ...

Of the two sister angiotensin II receptors, one has become a reliable drug target, while the other has remained something of a puzzle. The reliable one, known as AT1, has inspired many of the ...

The effects of angiotensin II are mediated by two receptors, the AT1 receptor and the angiotensin II type 2 (AT2) receptor. 16 AT1-receptor signaling can increase the production of TGF-β ligands ...

Angiotensin II receptor antagonists are agents used to modify the renin-angiotensin-aldosterone system (RAAS) through blocking angiotensin receptors. This has the effect of lowering blood pressure.

ACE/angiotensin II/AT1 leads to production of oxygen free radicals that impair the ability of the insulin receptor to mediate glucose regulation. This explains the link between diabetes and obesity.

Valsartan inhibits the effects of angiotensin II by selectively blocking the AT1 receptor, and also inhibits angiotensin II-dependent aldosterone release. Pages: 1 2.