Inflammation and metabolic stress combine to drive a new cell death pathway—mitoxyperilysis

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur ...

Scientists can finally answer an old question about cellular aging

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective ...
News-Medical.Net on MSN

Study reveals ATM kinase as the key driver of replicative senescence

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective ...
News-Medical.Net on MSN

Innate immunity and metabolic stress drive a unique form of cell death

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together.
EMBO Press

Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation

Degradation mechanisms of transcriptionally active aryl hydrocarbon receptor (AHR) are unclear. This work reveals that PARP7 ...