Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, largely due to metastasis and therapeutic ...
Morning Overview on MSN
Molecular switch lets cancer cells dodge death
Cancer’s deadliest talent is not rapid growth but the ability to sidestep the internal programs that should make damaged ...
Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.
13hon MSN
Inflammation and metabolic stress combine to drive a new cell death pathway—mitoxyperilysis
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur ...
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective ...
News-Medical.Net on MSN
Study reveals ATM kinase as the key driver of replicative senescence
After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres-the protective ...
News-Medical.Net on MSN
Innate immunity and metabolic stress drive a unique form of cell death
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together.
Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation
Degradation mechanisms of transcriptionally active aryl hydrocarbon receptor (AHR) are unclear. This work reveals that PARP7 ...
Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease, affecting up to one in three people in the general population, with an ...
Developmental patterning pathways are essential for establishing the structural and functional architecture of the brain.
Astrocytes have historically been viewed as mere supportive cells within the brain, but recent advances have positioned them as central to understanding ...
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