There are very few effective treatments to slow the symptoms of amyotrophic lateral sclerosis, also known as motor neurone ...

Distribution of Ranvier nodes along myelinated axons is a critical determinant of conduction velocity, significantly influencing spike arrival timing and hence neural circuit function. The patterns of ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

Purpose: The pharmacology, pharmacokinetics, clinical efficacy, and safety of rasagiline are reviewed. Summary: Rasagiline is a novel, investigational propargylamine that irreversibly and ...

Abstract: From biological and artificial network perspectives, researchers have started acknowledging astrocytes as computational units mediating neural processes. Here, we propose a novel ...

aThe Cardiac Exercise Research Group at the Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway ...

Astroglia a potential disruptor of sleep oscillations that lead to epilepsy. Astrocyte dysfunction disrupts sleep-linked brain rhythms, resulting in an increased frequency of slow-wave sleep state ...

Figure 4. ApoE4 contributes to increased susceptibility to BBB dysfunction. ApoE4 derived from astrocytes and pericytes leads to decreased LRP1 expression on pericytes, resulting in activation of the ...