Major depressive disorder affects hundreds of millions worldwide, but a key to understanding its origins may lie in the brain ...

Furthermore, they discovered a critical mechanism involving activated microglia and astrocytes that resulted in sustained neuroinflammation in MDD. The first step of the mechanism was the release ...

“Astrocytes are really bushy,” Williamson says. They have a complex morphology with lots and lots of micro or nanoscale processes that infiltrate the area surrounding them.

Indeed, a few morphology-related genes, including FERMT2 and Slc1a2, appeared to be linked to AD, amyotrophic lateral sclerosis, and multiple sclerosis. All told, the authors concluded that loss of ...

“Astrocytes and microglia not only changed their morphology, we also found alterations in specific markers that are characteristic to disease-associated microglia,” said Hösli.

"Astrocytes and microglia not only changed their morphology, we also found alterations in specific markers that are characteristic to disease-associated microglia," says Hösli.

Researchers at Baylor College of Medicine reveal that astrocytes, the most abundant cells in the brain, play a direct role in the regulation of neuronal circuits involved in learning and memory ...

Adult astrocytes are key to learning and memory Date: April 23, 2020 Source: Baylor College of Medicine Summary: Researchers have discovered that astrocytes, the most abundant cells in the brain ...

They analyzed several brain regions, looking for alterations in astrocyte morphology, physiology and gene expression signatures. “We found that NFIA-deficient astrocytes presented defective shapes and ...

Human astrocytes are categorized based on their anatomical location and cellular morphology into protoplasmic astrocytes, fibrous astrocytes, interlaminar astrocytes, polarized astrocytes, and ...