Disrupted Bile Metabolism Linked to Liver Cancer A critical imbalance in bile acids can trigger liver diseases, including cancer.

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by ...

Study findings indicate therapeutic potential of microbiome-based intervention to restore bile acid balance and promote gut healing in ulcerative colitis.

“Our findings highlight the potential of microbiome-targeted strategies to modulate bile acid metabolism and promote gut healing,” says Antoine Jalil, the first author of the study.

They discovered that the liver tumor samples had elevated levels of conjugated bile acids, then asked whether this class of bile acids was directly contributing to cancer development.

For nearly a century, scientists have been trying to understand why many animals live longer, healthier lives when they have less to eat. Now, work led by Sheng-Cai Lin, Chen-Song Zhang, and Xianming ...

Humans and other organisms make bile acids to help solubilize fats for digestion. But once they’re secreted into the gut, these molecules become subject to secondary metabolism.

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut ...

Bile reflux occurs when bile, a liquid that the liver makes, flows back up into the stomach or esophagus. Learn more about its symptoms and treatment.

Medications that target bile acid-triggered pathways and combination therapies could be the key for treating nonalcoholic steatohepatitis for young people with obesity and type 2 diabetes ...

Bile Acid: A Comprehensive Exploration of Function and Metabolism Summary In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various ...