The San Francisco Giants have an opportunity to make some big changes to their roster this offseason. After missing the ...

San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback ...

Postgame, both Murray and Brock Purdy had a brief interaction following a hard-fought matchup. The two young quarterbacks, ...

Another week, another full slate of NFL action nearly in the books. And Week 5 has had no shortage of drama up to this point, ...

Watch San Francisco 49ers wide receiver Brandon Aiyuk's Week 5 highlights from his 147-yard game against the Arizona Cardinals.

Tom Brady awards Arizona Cardinals QB Kyler Murray with the LFG Player of the Game after his dominant performance against the ...

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

What do the San Francisco 49ers and a cookie have in common? They both crumble when the pressure is on. For the second time this season, the 49ers waste another ...

Watch San Francisco 49ers quarterback Brock Purdy's best plays vs. the Arizona Cardinals in the Week 5 matchup.

In the final minutes of the game, two important plays helped the Arizona Cardinals secure a win over the San Francisco 49ers.

In 2005, the USS San Francisco, a Los Angeles-class nuclear-powered submarine, collided with an uncharted underwater mountain ...