A landmark study by WEHI scientists has shed new light on one of the most fundamental mysteries of biology: how cells divide ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

The capability of tracing a food product along its production chain is important to ensure food safety and product authenticity. For this purpose and as an application example, recently developed ...

Metabolic labeling of DNA has traditionally been performed using [3 H]thymidine or BrdU.These labels are limited in terms of their subsequent visualization, requiring either autoradiography, or DNA ...

All the latest science news on dna replication from Phys.org. Find the latest news, advancements, ... Live-cell labeling sheds light on how our DNA is packed and behaves in cells.

Multiple forms of DNA damages such as base modifications, double-strand breaks, and mispairings are related to inheritable diseases, cancer, and aging. Here, the structural changes of duplex DNA upon ...

AbstractFocal amplifications of oncogenes are important cancer drivers. They can occur on chromosomes or in the context of circular extrachromosomal DNA (ecDNA). Many key features of ecDNAs were ...

Ensuring that DNA replication occurs at the right stage of the cell cycle is of crucial importance in biology. In bacteria, DNA replication begins with the assembly of a DNA-protein complex called the ...

DNA replication is a fundamental process required of all cell types (1–3).Replicative polymerases (Pol), such as the leading-strand polymeraseε (Polε) and lagging-strand Polδ, synthesize DNA with ...