Topiramate, also sold under the brand name Topamax, is a drug approved by the U.S. Food and Drug Administration (FDA) for ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

The universe has no brain. It has no gray matter, no nervous system, no neurons firing electrical impulses—and yet, that ...

By working through example problems ... specific parts of enzymes called active sites which makes enzymes specific to their substrates, like keys fitting into locks. This is known as the lock ...

By bridging the gap between botanical science and material innovation, aloe vera gel extract is evolving from a skincare ...

Regular physical activity, such as dance or targeted exercise, can slow the progression of Parkinson’s disease, helping ...

A study by researchers at Fred Hutch Cancer Center published in Nature revises the standard story about transcription factors ...

Another reason for choosing a particular modality is that it is a team’s specialty. Strategic choices can be less about determining which modality best fits a potential target than about choosing a ...

For example, the co-administration of gemfibrozil with the ... strong time-dependent inhibitor of CYP2C8 leading to marked clinical DDIs with the substrates of this enzyme. Patients on clopidogrel and ...

provides valuable mechanistic insights into the conformational dynamics of Insulin Degrading Enzyme (IDE), a zinc metalloprotease ... able to release cleavage products and bind new substrate. Here, we ...