Willis will receive his Pro Football Hall of Fame Ring of Excellence on Sunday when the 49ers face the Cardinals.

Kyler Murray threw three TD passes, two to Greg Dortch in a 37-27 upset win in a Madden simulation of the Week 5 game.

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

The Arizona Cardinals and San Francisco 49ers will kick off Sunday afternoon from Levi’s Stadium at 1:05 p.m. Arizona time.

This was the first week that players placed on injury lists before the season opener could be brought back to practice and ...

Brissett failed to reach 200 yards passing for a fourth straight game, threw an interception that was returned for a ...

Even after all the success the San Francisco 49ers had the past few seasons, a two-game skid and a string of injuries early ...

The Bills are 3-0 after a blistering start and it is a surprise to see them as underdogs considering their recent ...

The Minnesota Vikings are 3-0 and perhaps the most impressive NFL team to date. It's easy to overreact this early in the campaign, but Minnesota has compelling ...

Tennessee's Sunday opponent, the Packers, could make for an under-the-radar Week 3 NFL survivor pick, even though their own quarterback situation is not optimal, as former Titans QB Malik Willis ...

It used to be Tom Brady. Since the future Hall of Fame quarterback was taken in the sixth-round (pick 199) in the 2000 NFL Draft, experts would mine the prospects year-after-year looking for the next ...

San Francisco 49ers wide receiver Deebo Samuel will be sidelined the next few weeks. On Monday, 49ers coach Kyle Shanahan told reporters that Samuel will miss "a couple weeks" due to a calf strain ...