Following the discovery of leptin in 1994, the scientific and clinical communities have held great hope that manipulation of the leptin axis may lead to the successful treatment of obesity.

D: It's a hormone produced by fat cells. Leptin plays a key role in regulating appetite and metabolism. When you eat, fat cells release leptin, which then binds to receptors in a part of your ...

Structure and function Leptin is a 16 kDa adipose-derived protein comprising 167 amino acids. The hormone is coded for by the ob gene which is located on chromosome 7 in humans.

In a new study, Yale researchers offer insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. Their findings advance knowledge about leptin and weight gain, and ...

Most leptin supplements don’t actually contain the hormone leptin. Research is unclear whether these supplements can help you lose weight, but some studies suggest they can influence leptin ...

Ghrelin and leptin are two hormones that are of great interest in appetite regulation. Leptin is commonly considered anorexigenic (i.e., appetite suppressant), while ghrelin is orexigenic (i.e ...

"The findings support the known role of leptin variations in late-life dementia risk by relating its deficiency with changes in white matter structure, which is an early event in the process of ...

Panel C shows the results after human embryonic kidney 293 (HEK293) cells were transiently transfected with empty vector or vector encoding nonmutant or D100Y leptin. After 48 hours, culture ...

The identified leptin variants were submitted to the ClinVar ... transfection or stable viral transduction. Details on protein structure modeling, activity, binding, internalization, and ...