Adding MF59 adjuvant to subvirion, egg-grown H5N1 vaccine results in lowering the antigen dosage required to elicit a putative seroprotective response in approximately 60% of the subjects to 15 ...

Most information can be found in the European public assessment reports (EPAR) of EU-registered vaccines that contain an adjuvant ( Table 1). The EPAR of the MF59-adjuvanted influenza vaccine ...

And last year, the HVTN 702 study of two co-administered HIV candidate vaccines from Sanofi Pasteur and GlaxoSmithKline, combined with GSK’s adjuvant MF59, was also discontinued due to a lack of ...

In 2021, for example, the HVTN702 study of two co-administered HIV candidate vaccines from Sanofi Pasteur and GSK, combined with GSK’s adjuvant MF59, was also discontinued due to a lack of efficacy.

Today, my answer is that it doesn't matter because the vaccine made with the existing virus, when administered with the adjuvant MF59, will induce antibodies that will interact with a mutated virus.

To address a current unmet need for more efficacious adjuvant regimens for completely resected melanoma, RELATIVITY-098 was designed to evaluate adjuvant NIVO + RELA FDC vs NIVO alone in pts after ...

The ESPAC-3 trial, 8 the largest adjuvant study in this setting, was a prospective, randomized phase III chemotherapy study of FU and folinic acid (n = 551) versus gemcitabine (n = 537); a third, ...

Patients who have cutaneous squamous-cell carcinoma with high-risk features are at risk for recurrence after definitive local therapy. The benefit of systemic adjuvant therapy options has not been ...

The interim analysis revealed a 17% absolute difference in DFS at 24 months, which translated into a 78% reduction in the hazard ratio in favor of biomarker-driven adjuvant therapy (95% CI 0.06-0. ...

CHICAGO — A 14-gene molecular assay could help predict which patients with early-stage non-small cell lung cancer will benefit from adjuvant chemotherapy, according to results of the AIM HIGH ...

CHICAGO — Adding adjuvant nivolumab to standard chemoradiotherapy significantly improved DFS for certain patients with locally advanced head and neck squamous cell carcinoma, according to ...