After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

Half of the 10 Sunday afternoon games on the Week 5 NFL schedule are divisional matchups, but oddly, none of them features a ...

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

San Francisco's defense rebounded against the Patriots but faces a tougher test in Murray's dynamic playmaking ability. Brock ...

An Aussie had a career day, and the rookie throwers are starting to make their mark as the NFL reached week five.

Why San Francisco 49ers changed their uniform for NFL Week 5 game against Arizona Cardinals Sunday, and why it's not the ...

The only game in Week 5 between teams with winning records, this matchup is the "Stefon Diggs Bowl," as the Texans’ wideout plays his former team for the first time. An NFL All-Pro four consecutive ...

With record heat descending on the Bay Area on Sunday, the NFL has denied the San Francisco 49ers' request to wear white ...

The San Francisco 49ers are preparing for their Week 5 matchup against the Arizona Cardinals under challenging weather ...