A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

Christian McCaffrey has missed the first four games of the season for the San Francisco 49ers due to bilateral Achilles ...

But the first series — a two-play, 72-yard touchdown drive, saw Campbell burned on a chunk-yard pass and then a 50-yard ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

Active for the Niners are two All-Pros who were questionable entering Sunday’s game after missing two practices last week: ...

The defense wilted in the heat, the offense couldn't finish drives or protect the ball and the San Francisco 49ers blew ...

Chad Ryland, recently on the Arizona Cardinals' practice squad, kicked in place of the injured Matt Prater and made a 35-yard ...

The NFL no longer has any winless teams after the Jaguars triumphed, and several other teams broke through. What were the ...

While Christian McCaffrey is making encouraging strides with his Achilles issues, the 49ers will suit up injured stars George ...

It’s even hotter than was expected on a record-breaking day at Levi’s Stadium for Sunday’s San Francisco 49ers game — and the ...

The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).

This marked the second time this season that San Francisco (2-3) blew a double-digit lead in the fourth quarter to a division ...