Version of Record: This is the final version of the article. In this paper, Wang et al show that differentiated peridermal cells of the zebrafish epidermis extend cytoneme-like protrusions toward the ...

Rajwinder Lehal, Jelena Zaric, Michele Vigolo, Charlotte Urech, Viktoras Frismantas, Nadine Zangger, Linlin Cao, Adeline Berger, Irene Chicote, Sylvain Loubéry, Sung ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

The resistance to chemotherapeutics is one major challenge to clinical effectiveness of cancer treatment and primarily interpreted by various biochemical mechanisms. This study provides compelling ...

When Apple introduced its new design language for the MacBook Pro with a notch at the top, I was flabbergasted. I was watching the event on a Dell XPS 15’s OLED screen and kept wondering why Apple ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. The significance of ...

From the Seattle Children's Research Institute (V.J.H.), Departments of Pediatrics and Pathology (M.W.M.), and The Institute of Stem Cell & Regenerative Medicine (M.W.M.), University of Washington, ...

When Apple unveiled the new iPhone 14 at its annual fall keynote on Sept. 7, fans noticed a slight change to the design of the phone for the higher priced models. The change comes to the notch of the ...

Specified intestinal epithelial cells reprogram and contribute to the regeneration and renewal of the epithelium upon injury. Mutations that deregulate such renewal processes may contribute to ...

The endocardium is a crucial signaling center for cardiac valve development and maturation. Genetic analysis has identified several human endocardial genes whose inactivation leads to bicuspid aortic ...