This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

A version of this article appears in print on , Section B, Page 11 of the New York edition with the headline: Ed Smylie Dies at 95; His Team of Engineers Saved Apollo 13 Crew.

Insilico Medicine Ltd. has identified postsynaptic density-95 (PSD-95) protein inhibitors acting as neuroprotective agents reported to be useful for the treatment of epilepsy, anxiety disorders, ...

Additionally, these results are in agreement with the recent observation that NFL in the CSF, in contrast to neurogranin, is more increased in CJD VV2 cases than in MM1, 34 with VV2 cases showing ...

In a new study that could pave the way for new treatments targeting age-related cognitive decline, researchers have discovered that low-dose, long-term administration of a key cannabis component can ...

To this end, we used a mouse model deficient for DNA-PKcs to show that its kinase activity has a role in synaptic plasticity. We find that in DNA-PKcs −/− mice LTP is impaired by lack of PSD-95 ...

University of Copenhagen has described cyclic peptides acting as postsynaptic density-95 (PSD-95) protein inhibitors reported to be useful for the treatment of neuropathic pain.

PSD-95 constitutes therefore an ideal candidate for developing labeling strategies that do not affect the protein expression levels. By exploiting evolved binders, a single-chain variable fragment ...

Studies on the following synaptic markers were included: structural dendritic changes (e.g., dendritic spine density, arborization), PSD-95, synapsin-1, synaptophysin-1, synaptotagmin-1, and SV2A.

The levels of synaptophysin (SYN) and postsynaptic density protein 95 (PSD-95) in the hippocampus were also examined by western blotting. Here we showed that anesthesia/surgery impaired reference ...