Genetic changes can signal evidence of disease, but pinpointing which genes and what's changed can be difficult.

Penn Medicine researchers have identified genetic conditions in a large percent of adults admitted to the intensive care unit ...

Genetic changes can signal evidence of disease, but pinpointing which genes and what's changed can be difficult.

During and following congenital heart surgery, children who reside in nonmetro areas have increased risk of in-hospital and postdischarge mortality.

A recent study led by Paul DeCaen, Ph.D., associate professor of Pharmacology, has identified novel molecular mechanisms by ...

Background Coarctation of the aorta (CoA) has good modern results, but large multicentre longitudinal data on outcomes, especially hospital resource utilisation through childhood and adolescence, are ...

Since the emergence of the Zika virus epidemic in 2014 and the associated novel sequalae that emerged, much has been learned about the effects of antenatal exposure to Zika virus. Zika virus in ...

Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and ...

These findings demonstrate that maternal obesity alone can result in cardiac defects through mechanisms similar to those associated with maternal hyperglycemia. This study provides valuable insight ...

Congenital heart defects: Causes and prevention The exact causes of congenital heart defects remain largely unknown. In some cases, a genetic abnormality may be found, which could be hereditary.

Genetic disorders are prevalent in patients with congenital heart disease (CHD), but genetic evaluations are underutilized and nonstandardized. We sought to quantify a dysmorphology score and develop ...