A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

With the San Francisco 49ers (2-3) and the Seattle Seahawks (3-2) squaring off on Oct. 10 at Lumen Field, Brock Purdy and ...

The 49ers just blew another 10-point fourth quarter lead and lost 24-23 to the Arizona Cardinals. Now the 49ers are 2-3. Here ...

How to watch Arizona Cardinals vs San Francisco 49ers in NFL Week 5 game today, with time, television channel, streaming ...

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook. San ...

San Francisco 49ers running back Christian McCaffrey won't return in Week 6, but will likely make his long-awaited comeback ...

Brock Purdy had two costly interceptions against the Cardinals, resulting in a disappointing one-point loss for the 49ers.

The defense wilted in the heat, the offense couldn't finish drives or protect the ball and the San Francisco 49ers blew ...

Chad Ryland, recently on the Arizona Cardinals' practice squad, kicked in place of the injured Matt Prater and made a 35-yard ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

With Moody sidelined, the 49ers had to pivot to a backup kicker. San Francisco has punter Mitch Wishnowsky serve as their ...

SANTA CLARA—The West Coast heatwave wreaked havoc on the 49ers’ practice schedule this past week, leading coach Kyle Shanahan ...