A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

The San Francisco 49ers haven't been healthy this season but have high hopes for the campaign and may look to make a trade.

The San Francisco 49ers are making a significant change to ... the 49ers are freeing up cap space by restructuring Samuel’s deal. The move was first reported on September 3 when ESPN reporter ...

The San Francisco 49ers will likely be active ahead of the Nov. 5 NFL trade deadline. Don't expect general manager John Lynch ...

The San Francisco 49ers have built a playoff-worthy roster, but they could see one of their top players jump ship to the Los ...

After cutting defensive tackle Arik Armstead in a salary-cap move in the offseason ... from the practice squad with T.Y.

The San Francisco 49ers haven't been listed as potential suitors for disgruntled Las Vegas receiver Davante Adams, but a well ...

The San Francisco 49ers' defensive line recently took a hit with the loss of Javon Hargrave along the interior. Coaches hope ...

In 2022, general manager John Lynch proved as much by boldly acquiring Christian McCaffrey —the reigning NFL Offensive Player ...

Quarterback Brock Purdy, who came out of a 27-24 loss to the Los Angeles Rams with a sore back, headed to practice Wednesday ...

There was some speculation the San Francisco 49ers may want to get involved in the trade market for Las Vegas Raiders wide ...