By designing proteins de novo scientists can more efficiently create novel therapeutics tailored for specific biological ...

The latest version of Google DeepMind and Isomorphic Labs’ AlphaFold model can predict the structure and relationships not only of proteins, but “all of life’s molecules”, according to its ...

One ring to bind them all. Using state-of-the-art cryo-electron microscopy, the research team was able to decipher the structure.To do this, the membrane proteins were shock-frozen in a solution ...

A high-level overview of Structure Therapeutics Inc. (GPCR) stock. View (GPCR) real-time stock price, chart, news, analysis, analyst reviews and more.

Abstract: In this paper, we propose a hybrid RNN/HMM system for protein secondary structure prediction, where each secondary structure segment is approximated by a second-order recurrent neural ...

A high-level overview of Cullen/Frost Bankers, Inc. (CFR) stock. View (CFR) real-time stock price, chart, news, analysis, analyst reviews and more.

In this study, we focused on the effect of the NP size (curvature) on the protein secondary structure using silica NPs (SiNPs) with diameters of 10 nm, 100 nm, 1 μm, and 10 μm. The secondary structure ...

The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within the inner and the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton. The importance of ...

The catalytic versatility of pentacoordinated iron is highlighted by the broad range of natural and engineered activities of heme enzymes such as cytochrome P450s, which position a porphyrin cofactor ...

We systematically train 36 PLM subnetworks targeting both sequence- and residue-level features at varying degrees of resolution using annotations defined by the CATH taxonomy and secondary structure ...