The focus of this review is on the development of small molecule tyrosine kinase inhibitors, and does not extend to other approaches that could be applied to disrupt the same pathways in clinical ...

As phosphorylation is a reversible process, the heterotrimeric serine/threonine phosphatase-2A (PP2A) balances the effect of DBT phosphorylation and promotes the stability of PER.

Serine/threonine kinase 24 (Stk24), also known as mammalian STE20-like kinase 3, belongs to the Ste20 serine/threonine protein kinase family and subfamily of germinal center kinase III kinases (18, 19 ...