This is despite the large number of potential therapeutic targets in which a regulatory role has been evidenced in both the pore pathway and the leak pathway ... also increases the expression of SCFA ...

Recently, a novel pathway, the miR-124/PTPN1 pathway ... within the brain through regulating the expression of SYN-2, 15-LOX, and VDR (synapsin-2, 15-lipoxygenase and vitamin D receptor). Similarly, ...

Scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional pain medications.

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

Vitamin K—natural phylloquinone and menadione—is rarely recognized but prominent when discussing nutrition intervention for ...

METHODS Immunolocalisation techniques using a rat monoclonal antibody to VDR and an alkaline phosphatase conjugated avidin/biotin detection system were used to examine VDR in 18 specimens of cartilage ...

Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, University of Tuebingen, Auf der Morgenstelle 8, Tuebingen 72076, Germany IFIT Cluster of Excellence EXC ...

There is clear evidence from large, high quality trials that adding an androgen receptor pathway inhibitor to standard of care substantially improves outcomes. However, clinical features of people ...