Researchers at the National Institutes of Health (NIH) have discovered clues as to how our bodies turn sensations such as heat and touch into signals sent to the brain—and how these signals can be ...

Division of Cardiology, Department of Medicine, University of California, Los Angeles (H.M.S., K.E.J., T.Q.d.A.V., E.J.T.). Division of Cardiology, Department of ...

receptor pathway in moderate to severe atopic dermatitis (AD). SM17 uniquely binds to the co-receptor for IL-25, a key alarmin, and blocks downstream signaling – disrupting the inflammatory cascade ...

Mechanistically, ORM2 effects were mediated by an inositol 1,4,5-trisphosphate receptor type 2-dependent calcium pathway. Conclusion This study reveals a paracrine communication circuit during ...

The Research Center for Computer-Aided Drug Discovery, The Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China University of Chinese Academy of Sciences, ...

a rare form of obesity that develops due to impaired signaling in the melanocortin-4 receptor pathway in the brain, which can lead to hyperphagia, reduced energy and weight gain, according to ...

Radioligand therapeutic agent For adults with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer who have been treated with an androgen receptor ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cholesteryl esters (CEs) and triacylglycerols ...

Amvuttra Gains Approval for Transthyretin Amyloid Cardiomyopathy Arbli (losartan potassium oral suspension) Angiotensin II receptor blocker For the treatment of hypertension, to lower blood ...

This study investigated the effects of paricalcitol, a synthetic vitamin D receptor (VDR) agonist, on intestinal I/R injury, focusing on the activating transcription factor 4 (ATF4)-C/EBP homologous ...