The most significant injury for the 49ers is to their franchise quarterback, Brock Purdy. He’s expected to miss several games ...

The San Francisco 49ers will be without their quarterback in Week 2 vs. the New Orleans Saints, but signs on their star RB ...

Get the latest 49ers vs. Saints Week 2 betting preview with injury updates, data-driven predictions, projected box score ...

San Francisco 49ers star Christian McCaffrey missed practice Friday and was being listed as questionable for the team's Week ...

The San Francisco 49ers begin their quest to a Supe Bowl with the season-opener against the Seattle Seahawks today. Find out ...

The San Francisco 49ers will have a full complement of offensive weapons when they face the Seattle Seahawks in Week 1.

The NFL has added a new twist this season with "rivalries" uniforms that eight different teams will don this year, and the ...

NFL Week 2 odds, picks, predictions, TV channel, streaming information for Sunday football game between San Francisco 49ers ...

San Francisco 49ers star running back Christian McCaffrey has been dealing with a calf injury that began to worry the entire ...

Even after coming away with a Week 1 win against an NFC West rival, the 49ers already are facing injury concerns just like ...

San Francisco 49ers running back Christian McCaffrey will suit up Sunday against the Seattle Seahawks. ESPN's Adam Schefter ...

Heading into Sunday's Week 1 matchup between the 49ers and the Seahawks, San Francisco running back Christian McCaffrey was ...