Two key protein structures in the body are being visualized for the first time, thanks in part to the latest technology in ...

A novel artificial intelligence (AI) tool has revealed how disease-linked proteins ... structure prediction. Unlike tools such as AlphaFold2 or AlphaFold3, which are trained on well-behaved ...

The researchers devised an innovative metric, known as the effective strain, [2] to detect small but important changes in protein structure that are linked to stability. Looking at thousands of ...

The team studied the cosolvent-dependent stability between native and denatured states in the yeast protein, GCN4-p1, which has a well-defined native structure that consists of coils and helices.

Failure to fold properly or maintain its three-dimensional structure can disrupt protein function and lead to disease. Insight into how protein folding stability is maintained will shed further ...

Failure to fold properly or maintain this three-dimensional structure can disrupt protein function and lead to disease. Insight into how protein folding stability is maintained will therefore shed ...

Department of Biomedical and Clinical Sciences, Cell Biology, Faculty of Medicine, Linköping University, Linköping 581 85, Sweden Ikerbasque, Basque Foundation for Sciences, Department of Physiology, ...

The open-source program can predict a protein's 3D structure from its sequence of amino acids, the building blocks that make up proteins. A protein's structure dictates its functions, so the ...