A marathon Sunday of Week 5 produced plenty of winners and losers, with the 49ers and Bills among the teams sparking concerns ...

Active for the Niners are two All-Pros who were questionable entering Sunday’s game after missing two practices last week: ...

Nice way for Lawrence to celebrate his 25th birthday.From NFL plays to college sports scores, all the top sports news you ...

Christian McCaffrey has missed the first four games of the season for the San Francisco 49ers due to bilateral Achilles ...

But the first series — a two-play, 72-yard touchdown drive, saw Campbell burned on a chunk-yard pass and then a 50-yard ...

Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two fourth-quarter scoring drives in the ...

Chad Ryland, recently on the Arizona Cardinals' practice squad, kicked in place of the injured Matt Prater and made a 35-yard ...

Brock Purdy threw two interceptions in the second half, Jordan Mason lost a fumble in the red zone and San Francisco allowed ...

While Christian McCaffrey is making encouraging strides with his Achilles issues, the 49ers will suit up injured stars George ...

In the second quarter, kicker Jake Moody exited the game with an apparent injury. Moody attempted to make a tackle during a ...

Here’s what fans and analysts were saying on Twitter after the 49ers dropped a shocking loss to the Cardinals in Week 5.

The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).