Missense mutations in LRRK2 were first identified as a cause of Parkinson’s disease (PD) in 2004. Subsequent studies showed that these mutations account for up to 10 percent of familial cases, with ...

Sleep tight, don’t let the tangles bite! In the May 27 Nature Neuroscience, researchers led by David Holtzman at Washington University School of Medicine, St. Louis, report that the sleep medication ...

A new class of AAVs has arrived. In six coordinated studies published on 21 May across Neuron, Cell, Cell Reports, and Cell Reports Methods, scientists unveil viral vectors fitted with ...

Cells feature an array of biological cascades to respond to stressors such as protein aggregates, viruses, and DNA damage. When these pathways are activated too much or for too long, things can go ...

The transmembrane protein 119 has a new job. Long known as a marker that distinguishes homeostatic microglia from macrophages and other myeloid cells, the protein also helps clear amyloid from the ...

In Alzheimer’s, and in mouse models of the disease, axon membranes bleb up in the vicinity of amyloid plaques. What if there was a way to prevent these dystrophic neurites from forming? As reported in ...

When cells are starved or distressed, RNA and RNA-binding proteins can coalesce into membraneless liquid droplets called stress granules. These shut down translation, helping cells conserve energy.

As a neuromodulator, norepinephrine is a powerful force in the brain. We all know it orchestrates rapid changes in behavior such as the fight-or-flight response. Fewer people know that astrocytes ...

What goes wrong first in the Alzheimer’s disease brain? Scientists led by Marc Aurel Busche of the U.K. Dementia Research Institute at University College London may have an answer. In the May 7 Neuron ...

The MCI-Park mice are compound mutant (Ndufs2fl/fl; DAT IREScre/+) animals in which Ndufs2, a gene encoding a core subunit of the mitochondrial respiratory chain, is selectively inactivated in ...

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This interactive resource organizes decades of data on biomarkers for Alzheimer's disease. Biomarker measurements from the cerebrospinal fluid and blood are curated from the primary literature and ...