An Aussie had a career day, and the rookie throwers are starting to make their mark as the NFL reached week five.

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

After swapping his cleats for a microphone, the spotlight during Sunday's game between the San Francisco 49ers and Arizona ...

This was easily Purdy's worst fantasy game through weeks, but fantasy managers shouldn't panic about their quarterback the way 49ers' fans are panicking about their team's Super Bowl hopes.

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

San Francisco's defense rebounded against the Patriots but faces a tougher test in Murray's dynamic playmaking ability. Brock ...

The San Francisco 49ers activate Kalia Davis, delay Ricky Pearsall's return as team manages injuries and roster moves.

Tagovailoa sustained at least the third concussion of his career in Week 2’s 31-10 loss to the Buffalo Bills. On Sept. 17, ...

What do you think of Robert Kraft's latest Nike Air Force 1? Check our Sneakers news for more upcoming releases and breaking ...

Isaac Guerendo only has six career NFL carries, but the rookie running back is making a strong impression on his 49ers ...

SANTA CLARA -- The 49ers are extremely hopeful about rookie running back Isaac ... That's a good feeling, right on the emblem ...

The home run run plays have been missing from the 49ers’ offense so far this season. That one evaded Guerendo on Sunday, but ...