The Super Bowl odds predict some familiar faces will battle to hoist the Lombardi Trophy this season. The Chiefs and 49ers, the Super Bowl 54 and 58 opponents, opened the season as the favorites ...

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The San Francisco 49ers activate Kalia Davis, delay Ricky Pearsall's return as team manages injuries and roster moves.

San Francisco's defense rebounded against the Patriots but faces a tougher test in Murray's dynamic playmaking ability. Brock ...

The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).

Why San Francisco 49ers changed their uniform for NFL Week 5 game against Arizona Cardinals Sunday, and why it's not the ...

The San Francisco 49ers will wear alternate throwback uniforms that feature white pants to prepare for projected record-breaking temperatures during ...

The following player has been promoted to the active roster from the team's practice squad: The 49ers announced that TE George Kittle has been ruled out for the team's Week 3 matchup vs.

Slowly but surely the 49ers are starting to place trust in their rookies. They showed it in their Week 4 win against the Patriots. There was one intriguing takeaway from the 49ers' Week 4 win ...

SANTA CLARA -- Jauan Jennings' agent messed up. This offseason, Jennings signed a two-year, $15 million extension with the 49ers. At the time it was a significant raise for Jennings, a former ...

The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...