The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The Arizona Cardinals and San Francisco 49ers play in Week 5 Sunday afternoon at Levi's Stadium with a 1:05 p.m. Arizona time ...

SANTA CLARA, Calif. -- It's not even five minutes into the San Francisco 49ers' second preseason game and quarterback Brock Purdy is visibly upset. Facing a third-and-8 at San Francisco's 41 ...

Jennings (ankle) had two receptions (on four targets) for 37 yards in Sunday's 23-17 loss to Minnesota. Jennings carried a questionable tag through the practice week after picking up an ankle ...

San Francisco 49ers star tight end George Kittle was carted off the field against the Minnesota Vikings. The good news is that Kittle just needed an IV because he was cramping. George Kittle #85 ...

The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

The Minnesota Vikings will host the San Francisco 49ers this Sunday at U.S. Bank Stadium in Minneapolis for week two of the NFL's regular season. Kickoff is scheduled for 1 p.m. ET and the game ...

The San Francisco 49ers didn't violate the NFL's rules regarding the injury status of star running back Christian McCaffrey in Week 1, the league announced on Friday. "We have looked into the ...

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The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...