The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).

The Arizona Cardinals and San Francisco 49ers play in Week 5 Sunday afternoon at Levi's Stadium with a 1:05 p.m. Arizona time ...

The San Francisco 49ers will wear alternate throwback uniforms that feature white pants to prepare for projected record-breaking temperatures during the team's Week 5 matchup with the Arizona ...

Slowly but surely the 49ers are starting to place trust in their rookies. They showed it in their Week 4 win against the Patriots. There was one intriguing takeaway from the 49ers' Week 4 win ...

The following player has been promoted to the active roster from the team's practice squad: The 49ers announced that TE George Kittle has been ruled out for the team's Week 3 matchup vs.

The 49ers called their win over the Patriots this past Sunday a work of art. Was it really, though? NFL.com's Eric Edholm wasn't impressed. That's why he placed the 49ers 12th in his Week 5 power ...

San Francisco 49ers head coach Kyle Shanahan addressed running back Christian McCaffrey's bilateral Achilles tendonitis for the first time, following comments made by general manager John Lynch.

As the San Francisco 49ers gear up for another run at a Super Bowl title, they find themselves with some unexpected holes to fill. All season, the 49ers' roster has been decimated by injuries ...

The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

The San Francisco 49ers are reinforcing the roster with two new additions, while also opening up the practice window for DL Kalia Davis. The injury bug has struck the 49ers over the past four ...

San Francisco 49ers wide receiver Deebo Samuel is active for Sunday's game against the New England Patriots. Samuel missed the 49ers' loss to the Los Angeles Rams last weekend with a calf injury.