The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

The Arizona Cardinals and San Francisco 49ers play in Week 5 Sunday afternoon at Levi's Stadium with a 1:05 p.m. Arizona time ...

"I had a conversation with Rhamondre and, quite frankly, this week he won't be starting," Mayo told host Scott Zolak. "I'll ...

It's awfully early in the 2024 season still, but the San Francisco 49ers already have a sense of urgency. The 49ers lost to the Minnesota Vikings on Sunday, but they've also been losing key ...

The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

The Minnesota Vikings will host the San Francisco 49ers this Sunday at U.S. Bank Stadium in Minneapolis for week two of the NFL's regular season. Kickoff is scheduled for 1 p.m. ET and the game ...

The San Francisco 49ers didn't violate the NFL's rules regarding the injury status of star running back Christian McCaffrey in Week 1, the league announced on Friday. "We have looked into the ...

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The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...

The San Francisco 49ers ruled out superstar running back Christian McCaffrey for the second consecutive week because of lingering calf and Achilles issues. Niners coach Kyle Shanahan said the ...

He missed the San Francisco 49ers' season-opener against the New York Jets on Monday night. His status blew up into controversy when head coach Kyle Shanahan did not confirm that he would not play ...