The San Francisco 49ers will wear alternate throwback uniforms that feature white pants to prepare for projected record-breaking temperatures during the team's Week 5 matchup with the Arizona ...

The Madden Curse has once again cast its shadow, this time over San Francisco 49ers superstar Christian McCaffrey (CMC).

The San Francisco 49ers announced updates to the Injured Reserve list and other practice squad moves. The 49ers have signed DL Jonathan Garvin and WR Terique Owens to the practice squad ...

San Francisco 49ers star receiver Deebo Samuel is expected to return from his calf injury in Week 4 against the New England Patriots, according to NFL Insider Jordan Schultz. Samuel sat out Week 3 ...

The San Francisco 49ers are back on track following their dominant 30-13 win over the New England Patriots and now find themselves in the top ten of the NFL power rankings of several national outlets.

Slowly but surely the 49ers are starting to place trust in their rookies. They showed it in their Week 4 win against the Patriots. There was one intriguing takeaway from the 49ers' Week 4 win ...

As the San Francisco 49ers gear up for another run at a Super Bowl title, they find themselves with some unexpected holes to fill. All season, the 49ers' roster has been decimated by injuries ...

The San Francisco 49ers have begun to turn the page to their younger players. They signaled those changes in their Week 4 victory against the New England Patriots. Rookie safety Malik Mustapha got ...

The 49ers aim to reverse a disappointing start to the season Sunday afternoon when they host the New England Patriots at Levi’s Stadium. Deebo Samuel and George Kittle are expected back after ...

The San Francisco 49ers will be without star running back ... The USA TODAY app gets you to the heart of the news — fast. Download for award-winning coverage, crosswords, audio storytelling ...