The 49ers' biggest issue was something that's plagued them all season: They had six trips to the red zone and scored just one ...

Cardinals quarterback Kyler Murray made big plays with his arm and his legs, running back James Conner fought for some tough yardage, and on the 49ers’ last offensive play, Brock Purdy got drilled as ...

The NFL denied the San Francisco 49ers' request to change to an all-white uniform set before the hottest game in Levi's ...

Kyle Juszczyk took a shot at Niner beat reporter Grant Cohn, implying that a married man is gay. Whether Juszczyk was saying ...

Half of the 10 Sunday afternoon games on the Week 5 NFL schedule are divisional matchups, but oddly, none of them features a ...

Christian McCaffrey had a chance to have a monstrous performance against the New York Jets on Monday night ... Just hours before the game, the San Francisco 49ers running back was ruled out ...

SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

The only game in Week 5 between teams with winning records, this matchup is the "Stefon Diggs Bowl," as the Texans’ wideout plays his former team for the first time. An NFL All-Pro four consecutive ...

There are many ways for the San Francisco 49ers to defeat the Arizona Cardinals. But there is one way that is the most beneficial to them. The 49ers have to est ...

Just four games into his tenure as New England Patriots head coach, Jerod Mayo is apparently already dealing with a crisis ...

San Francisco's defense rebounded against the Patriots but faces a tougher test in Murray's dynamic playmaking ability. Brock ...

Using Samuel in the backfield isn’t a novel concept, but it’s one the 49ers have gone away from since his breakout All-Pro ...