The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is associated with COPD regardless of smoking. Heterozygous MZ-AATD is recognised as a moderate deficiency state, increasing the risk of COPD ...

AIRNA’s lead program has the potential to be a best-in-class therapeutic for alpha-1 antitrypsin deficiency (AATD). AIRNA has headquarters in Cambridge, MA, with research operations in Tübingen ...

Alpha-1 antitrypsin deficiency (AATD) is underdiagnosed, with a significant gap between documented cases and estimated prevalence. Attempts to bridge this gap include published guidelines emphasising ...

Prime Medicine, Inc. announced the launch of a preclinical program targeting alpha-1 antitrypsin deficiency (AATD), a genetic disorder affecting lung and liver function, utilizing their ...

Korro Bio, Inc. has completed dosing for the first two cohorts in its Phase 1/2a REWRITE clinical study of KRRO-110, aimed at treating Alpha-1 Antitrypsin Deficiency (AATD), with interim results ...

Your doctor may check your levels of alpha-1 antitrypsin ... People with low levels of AAT have a condition called alpha-1 antitrypsin deficiency and often develop COPD at ... Chest X-ray or CT scan.

TO THE EDITOR, Recently, the Brazilian Journal of Pulmonary Medicine published a review article on alpha-1 antitrypsin deficiency (AATD), 1 which addresses the diagnosis and future prospects for ...

Background Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that ...

The most common genetic form of emphysema, alpha-1 antitrypsin deficiency is an inherited condition that affects the body's ability to produce a protein (alpha-1) that protects the lungs. It can ...

In some cases, emphysema can also be due to a genetic condition called alpha-1 antitrypsin deficiency. Over 3 million people in the U.S. have emphysema, although many more are diagnosed with COPD. [5] ...