Among the 6 cases showing ANCA fluorescence on ethanol- or formaldehyde-fixed substrate slides, 16.7% tested strongly positive for antiproteinase 3 antibody by ELISA. Infection with the Omicron ...

Objective Autoimmune hepatitis and primary sclerosing cholangitis are chronic inflammatory disorders of unknown aetiology, frequently associated with the presence of perinuclear antineutrophil ...

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is characterised by a small to medium-size vasculitis and the presence of ANCA. AAV includes ... Positive test for either MPO-ANCA ...

Recent randomized, controlled trials suggest that B-cell-depletion therapy with rituximab effectively induces remission in anti-neutrophil-cytoplasmic-antibody-associated vasculitis but is ...

For roughly 400 years, microscopes have allowed us to observe increasingly smaller details. Today's most advanced instruments ...

In 1990, Koderisch et al. were the first to report the presence of 'false-positive' ANCAs by indirect immunofluorescence and anti-myeloperoxidase antibodies by enzyme-linked immunosorbent assay in ...

We present a discussion of a middle-aged woman with a rare genetic mutation and catastrophic antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis. Although alpha-1 antitrypsin (AAT) ...

We have used immunofluorescence imaging to study binding of a monoclonal antibody fragment to subcutaneously implanted human melanoma cells in nude mice. The data acquired using this nontraditional ...

Background: Antineutrophil cytoplasmic antibodies (ANCA) with a C-ANCA or P-ANCA pattern are detected in ANCA-associated vasculitis (AAV). While in most patients with AAV a C-ANCA pattern is due to ...

Objective Treatment-refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a life-threatening condition without evidence-based treatment options. One emerging treatment ...