The ability to modulate high-mannose glycans during the production and reformulation of monoclonal antibodies (mAbs ... Steady-state glycosylation was reached after two days.

The ability to maintain antibody glycosylation profiles via polyamine modulation has numerous implications. Controlled glycosylation is crucial for optimizing therapeutic proteins, such as ...

they found over 30 different forms of the IgA1 and IgA2 antibodies. The glycans differed between the three experimental groups. The Crohn’s disease patients had IgAs with fewer branched sugars, but ...

Elina is a PhD candidate at the University of Toronto studying the regulation of microbial shikimate dehydrogenase enzymes. Elina joined the Creative Services Team as an intern and assists with ...

Rachel Jordan, PhD, a senior product manager at iBio, will present the poster (#P061), titled “Plant-Made Antibodies Show Superior Glycosylation Homogeneity While Retaining Pharmacokinetic Properties, ...

However, recent studies have described the influence of glycans, particularly sialic acid for other antibody classes. Here, we discuss the role of glycosylation, with a focus on terminal sialylation, ...

Antibody Dependent Cellular Phagocytosis (ADCP ... To immune-precipitate and analyze antigen-specific IgG-Fc glycosylation, streptavidin-coated magnetic beads (NEB Cat# S1420S) were coated with ...

As changes in the antibody’s carbohydrate chain can interfere with its effector functions, we compared the glycosylation patterns of both neutralizing and non-neutralizing IgG1 induced by pre-exposure ...

N58 glycosylation of PD‐1 promotes the interaction and contributes ... MAbs for tumor ICT and shed light for future design of next generation anti‐PD‐1 antibodies. N‐Glycan MS was conducted on an LTQ ...