Bile Acid Metabolism. Bile acids undergo a complex metabolic cycle known as the enterohepatic circulation. After aiding in digestion, bile acids are absorbed in the ileum and transported back to the ...

Feedback regulation of bile acid synthesis by bile acids was already known, but the responsible receptor remained elusive until the discovery of FXR. 13,14 Upon binding of bile acids, FXR induces ...

Bile acids are well recognized as essential for regulating cholesterol homeostasis and the digestion and absorption of fat through the intestine. In recent years they have emerged as signaling ...

SCARB2 Deficiency and Gut Dysbiosis: Scarb2 deficiency in mice is associated with gut dysbiosis and altered bile acid pools, leading to hyperactivation of FXR in the intestine, which impairs ...

Synthesized in the liver, bile acids play diverse roles in digestion and metabolism. However, when their processes are disrupted, disease can occur. Scientists seek advanced technologies to better ...

More information: Yuchen Liu et al, Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation, Nature Communications (2025). DOI: 10.1038/s41467 ...

Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat. They ...

Liver is the major organ for metabolism of sulfur amino acids (methionine, cysteine, taurine) and expresses high levels of sulfur amino acid synthesis and metabolising enzymes. Dietary intake ...

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon. EMBO Molecular Medicine , 2025; DOI: 10.1038/s44321-025-00202-w Cite This Page : ...

In a paper in Nature, researchers at the Chinese Academy of Sciences and Xiamen University report that they have identified one such caloric restriction mimetic—a bile acid called lithocholic ...

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut ...