Interstitial lung abnormalities (ILAs) are parenchymal lung changes found on high-resolution CT. In routine use of high-resolution CT, non-specific findings are frequently reported, which has prompted ...

According to data from the Health Insurance Review and Assessment Service in 2023, there are an estimated 15,000 patients ...

Background Prior work suggests different interstitial lung diseases (ILDs) that share the radiological usual interstitial pneumonia (UIP) pattern have an overall worse prognosis. However, ...

Novel oral agent nerandomilast slowed lung capacity decline in patients with non-idiopathic pulmonary fibrosis (IPF) interstitial lung disease (ILD) with a progressive pulmonary fibrosis phenotype ...

Endeavor’s lead candidate, ENV-101 (taladegib), is an inhibitor of the Hedgehog signaling pathway in development for fibrotic lung diseases, including idiopathic pulmonary fibrosis (IPF).

Pulmonary fibrosis is characterized by scarring of lung tissue, decline in lung function, reduced exercise capacity, and quality of life, and is associated with increased mortality.

Background A polymorphism (rs35705950) 3 kb upstream of MUC5B , the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We ...

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause; imaging and histology results indicate fibrosis and the characteristic features of usual interstitial pneumonia (UIP). 1 ...

Efforts to improve imaging of the fibrotic lung have included developing molecular probes to target areas of fibrosis or fibrotic activity with greater specificity to complement the structural ...

ABSTRACT: Purpose: Studies on imaging findings in mixed connective tissue disease (MCTD) are limited. This study assessed the relationship between CT-derived parameters (pulmonary artery diameter [PAD ...

Dr Jeffrey Swigris and Janet Talbert discuss the current understanding of the genetics of pulmonary fibrosis, explore the identified genetic pathways, and discuss future research directions.