The idea for a conditional pathway for rare disease drugs is not new, he said, noting that former acting FDA Commissioner Janet Woodcock has also advocated for such an initiative. In 2016, Woodcock ...

ABSTRACT: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart ...

This finding confirmed that the MyoVa-NL2 interaction is crucial for the regulation of anxiety and that the pathway involving Src kinase, calmodulin, MyoVa, and NL2 is a critical mechanism through ...

Several Ca 2+-dependent pathways are described that modulate gene expression by signal transduction to transcriptional regulators. In cardiomyocytes, well-characterized signaling patterns in this ...

Skeme of the molecular mechanism of regulation of fungal metabolism by the calcium-calmodulin-calcineurin pathway. Numerous stressing signals interact with GPCRs receptors in the cell membrane ...

Introduction. Calcium/calmodulin (Ca 2+ /CaM)-mediated signaling plays important roles in sensing and transducing environmental stimuli and developmental cues (Du and Poovaiah, 2005; Poovaiah et al., ...

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a chloride channel located in the apical membrane of epithelia cells. The ...

But the underlying mechanism was attributed to upstream regulators such as PI3K or isoforms of PKC. More definitive roles of calcium and its signaling mediator calmodulin (CaM) in mTORC1 signaling ...

Calmodulin is one of the most important proteins utilized in signal transduction pathways, the means by which a cell reacts and responds to changes in the environment. Researchers think that the ...